Wound Healing Properties of Ethanolic Extract of Acrostichum aureum and Acrostichum speciosum Rhizome in Rats

Abstract

This paper presents the assessment of wound healing properties of ethanolic
extract of Acrostichum aureum and A. speciosum in rats. It was carried out on
6 treated groups with 6 rats each group. The excisional wound was made on
the dorsal interscapular region of each rat by a 6 mm biopsy punch. T1 and T2
were treated with 5% and 10% A. aureum ethanolic extract in aqua cream,
respectively. Meanwhile, T3 and T4 were treated with 5% and 10% A.
speciosum ethanolic extract in aqua cream, respectively. Solcoseryl jelly and
aqua cream were used as positive and negative controls. The treatments were
applied topically twice daily, wound contraction and period of epithelization
were measured every 2 days. The results showed that wound treated with 10%
A. speciosum (T4) exerted faster wound contraction significantly (p < 0.05)
compared to the negative control. It was also enhanced epithelization period
(9.33 ± 3.20 days) of the wounds significantly (p < 0.05). In conclusion, these
results strongly suggested the beneficial effects of both plant extracts for
enhancing wound healing process.